Accelerated tumour growth due to immunotherapy: Fact or fiction?

Dr Marina Garassino speaks to ecancer at the 2019 American Association for Cancer Research (AACR) meeting about increased tumour growth as a result of immunotherapy in hyper-progressive cancer patients.

She addresses the divided opinions regarding this phenomenon - in which some oncologists believe the increased tumour growth seen in these patients is simply a representation of a more aggressive disease. However, other oncologists believe a subset of patients are susceptible to an acceleration in tumour growth.

Dr Garassino describes the discovery of an immune phenotype, characterised by PDL-1/CD33/CD163 expressing macrophages that may exist in these patients.

Dr Garassino also mentions a prospective trial that will aim to examine this phenomenon, along with a pre-clinical study that has reproduced this occurrence in animal models.

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fiction?